The Amorphous Cinchona Alkaloids
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چکیده
Quinoidine was greater than that of Quinine and this honour has often been awarded to it since, though very little of the drug appears to have been used except as a tonic for horses. Major Waters' recent paper in the IMG seems to be having a greater effect on its sale. In every Quinine factory Quinine alone has been the important product. The other alkaloids are listed and occasionally one or other has had a short boom, when
منابع مشابه
Transformation of Cinchona alkaloids into 1-N-oxide derivatives by endophytic Xylaria sp isolated from Cinchona pubescens.
The microbial transformation of four Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) by endophytic fungi isolated from Cinchona pubescens was investigated. The endophytic filamentous fungus Xylaria sp. was found to transform the Cinchona alkaloids into their 1-N-oxide derivatives.
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We report that an endophytic filamentous fungus species of the genus Diaporthe isolated from Cinchona ledgeriana (Rubiaceae) produces Cinchona alkaloids (quinine, quinidine, cinchonidine, and cinchonine) upon cultivation in a synthetic liquid medium. This study provides evidence that Cinchona alkaloids are produced not only in Cinchona plant cells, but also in the endophytic microbe cells, and ...
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Cinchona alkaloids (Figure 1.1), isolated from the bark of several species of cinchona trees, are the organic molecules with the most colorful biography [1]. Their history dates back to the early seventeenth century when they were first introduced into the European market after the discovery of the antimalarial property of cinchona bark and the subsequent isolation of its active compound, quini...
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Today, cancer remains one of the major diseases that lead to death. The main obstacle in chemotherapy as a main cancer treatment is the toxicity to normal cells due to Multidrug Resistance (MDR) after the use of anticancer drugs. Proposed solution to overcome this problem is the use of MDR efflux inhibitor of cinchona alkaloids which is delivered together with anticancer drugs encapsulated in t...
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عنوان ژورنال:
دوره 48 شماره
صفحات -
تاریخ انتشار 2016